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Major histocompatibility complex proteins (MHC) I and II on the surface of a dendritic cell
The peptide tirzepatide (Mounjaro) activating the GLP-1 receptor
Neutralizing monoclonal antibody binding to influenza virus hemagglutinin
Neurons with Lewy bodies
Exosomes, cross section showing proteins and mRNA
Organoid tissue. An organoid is a miniaturized and simplified version of an organ produced in vitro.
Immunotherapy of Alzheimer's disease. Antibody binding to an amyloid beta fibril.
Exosomes, cross section showing proteins and mRNA
PTEN-induced kinase 1 (PINK1) phosphorylates ubiquitin (yellow) on the outer mitochondrial membrane. Parkin (red) will bind afterwards to ubiquitin.
The enzyme New Delhi Metallo-beta-Lactamase-1 (NDM-1, blue) in complex with the flavonol inhibitor morin. NDM1 has devoloped to a global threat by confering resistance to all common β-lactam antibio
T-cell receptors and CD8 and CD4 co-receptors on a killer and a helper T-cell
Chikungunya viruses. The Chikungunya disease has become a global health concern.
The RNA polymerase II transcribing DNA into RNA.
Neutralizing monoclonal antibody in complex with Herpex Simplex virus 1 (HSV 1) glycoprotein B trimer
Activated spliceosome. The spliceosome removes non-coding regions (introns) from pre-mRNA, leaving the coding regions (exons) to form mature mRNA.
The vascular endothelial growth factor (VEGF) promotes blood vessel formation (angiogenesis)
Oncogene: DNA mutation leads to mutated KRAS protein
LDL particles. Low-density lipoprotein particles transport lipids like cholesterol, phospholipids and triglycerids
UCC118 Rool RNA (hexameric RNA). Stable RNA-based therapeutics.
Tumor
Immune checkpoint inhibitors: PD-1, CTLA-4 and PD-1 blocked by therapeutic antibodies
Epigenetics: DNA methylation by the DNA methyl transferase I (DMNT1)
Argonaute protein complexed with double stranded microRNA. Guide miRNA strand in red.
The GLP-receptor agonist tirzepatide (Mounjaro) before binding and bound to the receptor
Major histocompatibility complex proteins (MHC) I and II on the surface of a dendritic cell. Left MHC I, right MCH II. MHCII presents generally longer antigenic peptides (red) than MHC I.
GLP-1 receptor, inactivated and surrounded by an agonist (semaglutide, red) and G-proteins
Cancer immunotherapy: Therapeutic antibodies block HER2
26S proteasome. Proteasomes degrade unneeded or damaged proteins.
Epigenetics: DNA methyl transferase I (DMNT1) methylates DNA
Human epidermal growth factor receptor 2 (HER2) and HER3, pro-oncogenic complex
The amyloid beta peptide bound to the cell membrane, the free form aggregates to amyloid plaques.
The vascular endothelial growth factor receptor activated by VEGF. The activation leads to blood vessel formation.